Transnasal Cooling Promising for Migraine

April 14, 2025

SAN DIEGO — Neuromodulation of the sphenopalatine ganglion (SPG) through transnasal evaporative cooling is a promising nonpharmacologic treatment for acute migraine, results of a randomized controlled trial suggested.

The SPG, a nerve bundle located behind the nasal passages, has been implicated in migraine pathophysiology.

Mi-Helper is an investigational, semi-portable device, similar in size to sleep apnea machine, that uses dry, room-temperature air to cool the nasal cavity, which calms the SPG, relieving migraine pain and the need for medication.

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