Transnasal cooling device shows promise for migraine pain

April 7, 2025

SAN DIEGO — Significantly more patients with acute migraine who received a 10 L per minute dose of a transnasal cooling device had pain freedom at 2 hours vs. those who received sham, according to research presented at the AAN Annual Meeting.

“There is a critical need for alternative, acute migraine treatments, as many patients experience inadequate pain relief, intolerable side effects or contraindications to existing therapies,” MaryAnn Mays, MD, a neurologist in the Center for Neuro-Restoration at the Cleveland Clinic, said during AAN’s Top Science Press Conference. “Neuromodulation is an expanding field in headache medicine and multiple FDA-approved devices are available for migraine treatment.”

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